Mrs. Weer’d sends me this interesting story on Obesity and mice:
A novel animal model showed that the longer mice remained overweight, the more “irreversible” obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation.
Over time, the static, obese state of the mice reset the “normal,” body weight set point to become permanently elevated, despite dieting that initially worked to shed pounds, authors say.
“Our model demonstrates that obesity is in part a self-perpetuating disorder and the results further emphasize the importance of early intervention in childhood to try to prevent the condition whose effects can last a lifetime,” says senior author Malcolm J. Low, M.D., Ph.D., professor of molecular and integrative physiology and internal medicine.
Very interesting. This obesity rabbit hole really amazes me. I’ve always been of the “Eat less, exercise more” school, which still DOES have results, but more obese subjects tend to have worse results.
Of course understanding how this process works means that therapy the counteract the process could help many people!